Plenary Lectures

Wim Noorduin, AMOLF
Group Leader (AMOLF) and Professor (U. Amsterdam)

Make it with Minerals! Self-Organizing Complex Materials
Time: 11:05 a.m.

In this lecture, we explore how bioinspired self-organization processes can yield complex user-defined patterns of materials. By exploiting the interplay between reaction and diffusion rates, we mineralize nanoscopic building blocks that spontaneously organize into intricate patterns with sub-micrometer precision. Once these patterns are formed, we can convert the mineralized building blocks into different chemical compositions such as semiconductors and catalysts, while maintaining the initial pattern.
Finally, based on these insights we show how such conversion reactions can be exploited for detection of toxic lead by turning lead into light-emitting perovskite nanocrystals. This photoluminescent lead detection method enables rapid detection of lead to prevent lead poisoning and support forensic investigations. This test is currently used around the world by citizens, health care professionals, police forces, and environmental scientists.

Qi Jiang, Senior Principal Scientist
Bristol Myers Squibb

Deciphering Imatinib Multicomponent Crystals: Insights from X-Ray Crystallography and Solid-State NMR Spectroscopy
Time: 11:45 a.m.

The critical role of crystallization of active pharmaceutical ingredients (APIs) in drug development is widely explored, with particular emphasis on stability, solubility, and the feasibility of drug formulation and manufacturing. We explored polymorphism in APIs and the formation of multicomponent crystals, including salt and cocrystal screening, underscoring the significance of regulatory and intellectual property considerations in recognizing salts and cocrystals of solid forms. Our study led to the design of seven new multicomponent crystalline forms of imatinib, an oncology API. Using X-ray crystallography and solid-state NMR, we elucidated hydrogen bonding interactions and proton transfer, unveiling multicomponent interactions in the crystalline solid forms along the salt−cocrystal continuum. This research provides valuable insights into the structural details of solid forms of pharmaceutical compounds and emphasizes the importance of understanding solid-state interactions for the rational design of crystalline APIs, thereby enhancing the drug development process.

Tali Lemcoff
Ph.D. Student, Ben Gurion University

TBA
Time: 12:25 p.m.

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